Ovarian Hyperstimulation Caused by Gonadotroph Pituitary Adenoma – Review

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Ovarian Hyperstimulation Caused by Gonadotroph Pituitary Adenoma--Review.

Ovarian hyperstimulation syndrome (OHSS) occurs mostly as an iatrogenic complication of assisted reproductive technology. Gonadotroph pituitary adenomas are rarely associated with OHSS. To the authors' knowledge, to date only 30 cases of spontaneous ovarian stimulation associated with gonadotroph adenomas have been reported in women and only 2 in children. The most common symptoms in such cases...

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Gonadotroph pituitary macroadenoma inducing ovarian hyperstimulation syndrome: successful response to octreotide therapy.

We report a young woman with spontaneous ovarian hyperstimulation syndrome (OHSS), headaches, visual field defect and pituitary macroadenoma. She underwent transsphenoidal surgery with remission of OHSS. Immunohistochemical staining was positive for β-FSH and β-LH. Recurrence occurred after four years. The patient was treated with octreotide administration and conventional radiation therapy. Oc...

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Lineage-Specific Restraint of Pituitary Gonadotroph Cell Adenoma Growth

Although pituitary adenomas are usually benign, unique trophic mechanisms restraining cell proliferation are unclear. As GH-secreting adenomas are associated with p53/p21-dependent senescence, we tested mechanisms constraining non-functioning pituitary adenoma growth. Thirty six gonadotroph-derived non-functioning pituitary adenomas all exhibited DNA damage, but undetectable p21 expression. How...

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1. Halupczok J, Kluba‐Szyszka A, Bidzinska‐Speichert B, Knychalski B. Ovarian hyperstimulation caused by gonadotroph pituitary adenoma – Review. Adv Clin Exp Med 2015;24:695‐703. 2. Roberts JE, Spandorfer S, Fasouliotis SJ, Lin K, Rosenwaks Z. Spontaneous ovar ian hypers t imula t ion caused by a follicle‐stimulating hormone‐secreting pituitary adenoma. Fertil Steril 2005;83:208‐10. 3. Pentz‐Vi...

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hyperthyroidism that was difficult to control despite methimazole therapy. Her symptoms included headaches, palpitations, left-eye pain and frequent loose bowel movements. At referral, her serum thyroidstimulating hormone (TSH) level was 10.45 (normal 0.35–5.5) mIU/L and her free thyroxine (FT4) level was 17.8 (normal 11.5–22.7) pmol/L. A two-week methimazole withdrawal was attempted, resulting...

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ژورنال

عنوان ژورنال: Advances in Clinical and Experimental Medicine

سال: 2015

ISSN: 1899-5276

DOI: 10.17219/acem/25212